Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to lack of efficacious targeted therapies. The Nuclear Factor Activated T Cells (NFAT) family transcription factors well characterised as regulator the cell cycle and differentiation in lineage. Recent evidence has demonstrated that NFAT members may have roles regulating AML leukemogenesis resistance therapy leukaemia. Furthermore, gene expression data from patient samples show some NFATs are more highly expressed poorly differentiated after disease relapse, implying specific types AML. This review outlines for role healthy tissue explores how might regulate pathogenesis, highlighting potential target proteins therapeutically